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Volume 12, Number 6, 2007

Assessment of extracellular matrix proteins (laminin and fibronectin) in adenoid cystic carcinoma of salivary gland using morphometric method

Anna Wegner, Elżbieta Waśniewska, Wojciech Golusiński, Paweł Golusiński


Background Adenoid cystic carcinoma (ACC) is an uncommon form of malignant epithelial
neoplasm. It arises within major and minor salivary glands as well as mucous glands of the upper respiratory tract. It is characterized by high clinical malignancy, with unclear prognosis and unstable clinical course.
In histological examination of the tumour fi brillar structures are found in the extracellular matrix, containing fibronectin, type IV collagen and laminin.
Aim The aim of the present study was to assess the protein components of the extracellular
matrix – laminin and fibronectin.
Materials/Methods The study group included 30 patients with ACC of major salivary glands. The expression of immunohistochemical reaction for laminin and fi bronectin was assessed
using computerized analysis of obtained images.
Results The analysis showed no signifi cant differences in mean laminin and fi bronectin
positive reaction areas. Analysis of the proteins depending on histological ACC subtype showed that fibronectin expression was signifi cantly lower in tubular cancer compared to other types. For laminin no significant expression difference was found.
Conclusions In the future the immunochemistry of laminin and fi bronectin may become a
useful element of prognosis assessment in patients with adenoid cystic carcinoma.

Signature: Rep Pract Oncol Radiother, 2007; 12(6) : 339-343


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