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Volume 2, Number 1, 1997

Principles of total body irradiation

T. Grinsky, E. Briot, A. Bridier, A. Beadure


Total body irradiation delivered prior to bone marrow transplantation remains an important component of the conditioning regimen.
Proper engraftment of autologous or allogeneic bone marrow is possible because of the multifarious effects of high doses of ionising radiation on tumour cells and the host immune system We will broadly outline the techniques used to deliver total body irradiation, and the effects of ionizing radiation on normal and tumour cells from a biological and molecular point of view. Finally we w report the results of randomised clinical trials that have been conducted in our institution during the last ten years.

Signature: Rep Pract Oncol Radiother, 1997; 2(1) : 33-35

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