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Volume 4, Number 1, 1999

Concurrent chemoradiotherapy in limited-stage small-cell lung cancer. Results of a pilot study

Radkowski A, Korzeniowski S, Sas-Korczyńska B, Małecki K, Skołyszewski J.

Summary:

Between January 1994 and February 1998, 32 limited-stage small-cell lung cancer patients were treated with concurrent chemoradiotherapy. Follow-up time ranged from 4 to 34 months, (median 14 months). Complete regression was obtained in 22 of tnę 30 patients, who received at least four courses of EP chemotherapy and a tumour dose of 50 Gy or more. In all, 2-year actuarial disease-free survival was 21%. Brain metastases occurred in 8 (36.4%) patients with CR, in 5/7 (71.4%) patients without prophylactic cranial irradiation (PCI) and in 3/15 (20%) patients after PCI. The survival rate was Iower in patients with PCI, in whom chest irradiation was started later than one month from the beginning of course 1 of EP chemotherapy. We have suggested a modification of the treatment protocol.

Signature: Rep Pract Oncol Radiother, 1999; 4(1) : 3-8


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http://www.sciencedirect.com/science/journal/15071367/19/2