Dear Authors,
If you believe that your paper was mistakenly rejected by other leading journals and you do not agree with final decision, the editors of Reports of Practical Oncology and Radiotherapy offer new fast track review. You may submit your manuscript to Reports of Practical Oncology and Radiotherapy together with all prior peer-reviews obtained from the other journal and your rebuttal letter. We guarantee review based decision within 72 hours from the time we will receive your manuscript.

Fast track submission process: Please submit the manuscript with all reviews and rebuttal letter by email to Dr. Michal Masternak ( for fast review processing. To assure immediate attention the email title must to include: RPOR-fast track- Last Name First Name (of corresponding author).

Volume 22, Number 6, 2017

Dependence of micronuclei assay on the depth of absorbed dose

Seyed Mohammad Mahdi Abtahi, Seyed Mahmoud Reza Aghamiri, Masoumeh Yadolahi, Aziz Mahmoudzadeh



The purpose of the present study is to investigate the dependence of micronuclei response on the depth of absorbed dose.


One of the most common cytogenetic methods used for radiation dosimetry is micronuclei (MN). Being less complex and faster than other methods are two remarkable advantages of the MN method which make it suitable for monitoring of population. In biological dosimetry based on the micronuclei method, the investigation into the dependence of response on the depth in which dose is absorbed is significant, though has received less attention so far.

Materials and methods

Blood samples were poured in separate vials to be irradiated at different depths using a linear accelerator system.


According to the results, MN, as a function of the absorbed dose, had the best fitness with the linear–quadratic model at all depths. Furthermore, the results showed the dependence of MN response on the depth of absorbed dose. For doses up to 2 Gy, the maximum difference from the reference depth of 1.5 cm was related to the depth of 10 cm; however, by increasing the absorbed dose, the response associated with the depth of 20 cm showed the maximum deviation from the reference depth.


Consequently, it is necessary to apply a correction factor to the biological dosimetry. The correction factor is dependent on the depth and the absorbed dose.

Signature: Rep Pract Oncol Radiother, 2017; 22(6) : 470-476

« back